I have the same issue. I just upgraded from a original droid to a droid x2. I sometimes would have this problem on my old phone but never as frequent as I do on this one. The songs play fine in the android music player. But Poweramp just keeps getting the failed to play message. I tried moving them to a different folder, redownload the song, reinstall all of Poweramp and nothing. I emailed you as well. Hopefully i can get this working. This is the only music player i like to use. I love Poweramp please help!!!