Thanks to both of you for your input!
I failed to mention that I don't use any eq with my wired headphones. So I'm not too worried about distortion.
I did previously try AAudio. It does work with both high res and DVC, but I was receiving very brief audio dropouts. Also, audio ducking doesn't work at all with AAudio for me. (Not a huge issue, but wanted to note that)
Considering my music is almost entirely CD rips, I suppose DVC would make more sense to use. I'm not sure I can actually tell a difference between 48 kHz/16 bit and upsampled high res. But I do notice a volume improvement using DVC, and in theory, I like the idea of having the more direct path from Poweramp to output.
Thanks again!