So guys, here is the problem.
Redmi Note 8 Pro, MIUI 18.104.22.168
Poweramp v3 build 860 arm64
Noticed the problem, that even being enabled, Mi Sound Enhancer is not starting to work along with the song in Poweramp. If I turn it off and then On again, it will work and the sound changes, but stops (though it is still active in options menu) each time I switch from Poweramp to any other music source or phone call or even just pause the music. So i need to turn Mi Sound off again and then on again to get it working.
Does anyone face the issue or know how to fix it?